Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTA4REJ)

• DTT Name: Paired box protein Pax-5 (PAX5)
• Synonyms: PAX5; BSAP; B-cell specific transcription factor
• Gene Name: PAX5
• DTT Type: Literature-reported target; [1]
• UniProt ID: PAX5_HUMAN
• TTD ID: T29818
• Sequence:
  MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV
  SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA
  ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
  ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
  FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYP
  IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF
  PNPGLLGSPYYYSAAARGAAPPAAATAYDRH
• Function: May play an important role in b-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the cd19 gene, a b-lymphoid-specific target gene.
• KEGG Pathway: Transcriptional misregulation in cancer (hsa05202)
• Reactome Pathway: RUNX1 regulates transcription of genes involved in BCR signaling (R-HSA-8939245)

References

• [1] The expression of PAX5 in human transitional cell carcinoma of the bladder: relationship with de-differentiation. BJU Int. 1999 Jun;83(9):1039-44.