Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTA7YIZ)

DTT Name	Corticoliberin (CRH)
Synonyms	Corticotropin-releasing hormone; Corticotropin-releasing factor; Corticotropin releasing hormone; Corticotropin; CRF; Adrenocorticotropic hormone
Gene Name	CRH
DTT Type	Literature-reported target	[1]
UniProt ID	CRF_HUMAN
TTD ID	T64137
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQ ARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLL LPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQL AQQAHSNRKLMEIIGK
Function	Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. Hormone regulating the release of corticotropin from pituitary gland.
KEGG Pathway	Long-term depression (hsa04730 ) Alcoholism (hsa05034 )
Reactome Pathway	G alpha (s) signalling events (R-HSA-418555 ) Class B/2 (Secretin family receptors) (R-HSA-373080 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-Aminoisobutyric Acid	DM9GXFJ	Discovery agent	N.A.	Investigative	[1]
D-Phenylalanine	DMTUHFX	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------

References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.