Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTABCJ6)

• DTT Name: Lysophosphatidic acid receptor 5 (LPAR5)
• Synonyms: LPA-5; LPA receptor 5; GPR93; GPR92; G-protein coupled receptor 93; G-protein coupled receptor 92
• Gene Name: LPAR5
• DTT Type: Literature-reported target; [1]
• UniProt ID: LPAR5_HUMAN
• TTD ID: T18616
• Sequence:
  MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVY
  MCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRY
  AAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFS
  DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANL
  VIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFS
  AEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSL
  SSFTQCPQDSAL
• Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
• KEGG Pathway:
  Rap1 signaling pathway (hsa04015)
  Phospholipase D signaling pathway (hsa04072)
  PI3K-Akt signaling pathway (hsa04151)
  Regulation of actin cytoskeleton (hsa04810)
  Pathogenic Escherichia coli infection (hsa05130)
  Pathways in cancer (hsa05200)
• Reactome Pathway:
  G alpha (i) signalling events (R-HSA-418594)
  Lysosphingolipid and LPA receptors (R-HSA-419408)
  G alpha (q) signalling events (R-HSA-416476)

Molecular Interaction Atlas (MIA) of This DTT

4 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alkyl glycerol phosphate 18:1	DM3DERI	Discovery agent	N.A.	Investigative	[2]
LPA	DMI5XR1	Discovery agent	N.A.	Investigative	[3]
N-arachidonoylglycine	DM85RJ1	Discovery agent	N.A.	Investigative	[1]
octyl thiophosphatidic acid	DM2RJYO	Discovery agent	N.A.	Investigative	[2]

References

• [1] Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem. 2008 Jul 25;283(30):21054-64.
• [2] Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19;284(25):17304-19.
• [3] Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.