Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAEOJ4)

DTT Name	Bacterial UDP-N-acetylenolpyruvylglucosamine reductase (Bact murB)
Synonyms	UDP-N-acetylmuramate dehydrogenase; MurB
Gene Name	Bact murB
DTT Type	Literature-reported target	[1]
BioChemical Class	Short-chain dehydrogenases reductase
UniProt ID	MURB_ECOLI
TTD ID	T63359
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
Function	Cell wall formation.
KEGG Pathway	Amino sugar and nucleotide sugar metabolism (ecj00520 ) Peptidoglycan biosynthesis (ecj00550 ) Metabolic pathways (ecj01100 ) Biosynthesis of nucleotide sugars (ecj01250 )
BioCyc Pathway	MetaCyc:UDPNACETYLMURAMATEDEHYDROG-MON EcoCyc:UDPNACETYLMURAMATEDEHYDROG-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.