Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAFJUD)

DTT Name	Orotidine 5'-monophosphate decarboxylase (UMPS)
Synonyms	Uridine 5'-monophosphate synthase; UMP synthase
Gene Name	UMPS
DTT Type	Literature-reported target	[1]
BioChemical Class	Pentosyltransferase
UniProt ID	UMPS_HUMAN
TTD ID	T15851
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
Function	Catalyses the formation of uridine monophosphate (UMP), an energy-carrying molecule in many important biosynthetic pathways.
KEGG Pathway	Pyrimidine metabolism (hsa00240 ) Drug metabolism - other enzymes (hsa00983 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Pyrimidine biosynthesis (R-HSA-500753 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

7 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5-fluoro-6-amino-UMP	DM6QHIA	Discovery agent	N.A.	Investigative	[2]
5-fluoro-6-azido-UMP	DMZLJRS	Discovery agent	N.A.	Investigative	[2]
5-Fluoro-6-ethyluridine-5'-O-monophosphate	DMTAZ71	Discovery agent	N.A.	Investigative	[2]
5-fluoro-6-iodo-UMP	DM3LMIS	Discovery agent	N.A.	Investigative	[2]
6-Hydroxyuridine-5'-Phosphate	DMDMNQV	Discovery agent	N.A.	Investigative	[3]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[1]
Pyrazofurin	DMVJLSM	Discovery agent	N.A.	Investigative	[4]
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⏷ Show the Full List of 7 Investigative Drug(s)

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Uridine 5'-monophosphate synthase (UMPS) DME Info

Gene Name

UMPS

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
5	Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma: Dramatically responds one case in high OPRT expression. Rare Dis. 2016 Apr 5;4(1):e1165909.