Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAIY2U)

• DTT Name: HUMAN clathrin-mediated endocytosis (RME)
• Gene Name: RME
• TTD ID: T18226

Molecular Interaction Atlas (MIA) of This DTT

5 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[2]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[3]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[4]
Thiethylperazine	DMU3IET	Nausea	MD90	Approved	[3]
Triflupromazine	DMKFQJP	Nausea	MD90	Approved	[3]

References

• [1] Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19. Int J Biol Sci. 2020 Mar 15;16(10):1724-1731.
• [2] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
• [3] Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93.
• [4] Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.