Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTB3XAN)

DTT Name	Decorin (DCN)
Synonyms	SLRR1B; PGS2; PG40; PG-S2; Bone proteoglycan II
Gene Name	DCN
DTT Type	Literature-reported target	[1]
UniProt ID	PGS2_HUMAN
TTD ID	T67883
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Function	May affect the rate of fibrils formation.
KEGG Pathway	TGF-beta signaling pathway (hsa04350 ) Proteoglycans in cancer (hsa05205 )
Reactome Pathway	A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475 ) Chondroitin sulfate biosynthesis (R-HSA-2022870 ) Dermatan sulfate biosynthesis (R-HSA-2022923 ) CS/DS degradation (R-HSA-2024101 ) ECM proteoglycans (R-HSA-3000178 ) Defective B4GALT7 causes EDS, progeroid type (R-HSA-3560783 ) Defective B3GAT3 causes JDSSDHD (R-HSA-3560801 ) Defective CHST3 causes SEDCJD (R-HSA-3595172 ) Defective CHST14 causes EDS, musculocontractural type (R-HSA-3595174 ) Defective CHSY1 causes TPBS (R-HSA-3595177 ) Defective B3GALT6 causes EDSP2 and SEMDJL1 (R-HSA-4420332 ) Degradation of the extracellular matrix (R-HSA-1474228 )

References

1	Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker. Am J Obstet Gynecol. 2016 Sep;215(3):361.e1-361.e15.