Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBGWN3)

• DTT Name: Butyrophilin-like protein 3 (BTNL3)
• Synonyms: UNQ744/PRO1472; COLF4100; Butyrophilin-like receptor; BTNLR
• Gene Name: BTNL3
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Immunoglobulin
• UniProt ID: BTNL3_HUMAN
• TTD ID: T68206
• Sequence:
  MAFVLILVLSFYELVSGQWQVTGPGKFVQALVGEDAVFSCSLFPETSAEAMEVRFFRNQF
  HAVVHLYRDGEDWESKQMPQYRGRTEFVKDSIAGGRVSLRLKNITPSDIGLYGCWFSSQI
  YDEEATWELRVAALGSLPLISIVGYVDGGIQLLCLSSGWFPQPTAKWKGPQGQDLSSDSR
  ANADGYSLYDVEISIIVQENAGSILCSIHLAEQSHEVESKVLIGETFFQPSPWRLASILL
  GLLCGALCGVVMGMIIVFFKSKGKIQAELDWRRKHGQAELRDARKHAVEVTLDPETAHPK
  LCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQGFQAGKHYWEVDVGQNVGWYVGVCRD
  DVDRGKNNVTLSPNNGYWVLRLTTEHLYFTFNPHFISLPPSTPPTRVGVFLDYEGGTISF
  FNTNDQSLIYTLLTCQFEGLLRPYIQHAMYDEEKGTPIFICPVSWG
• Function: Regulate the homing and maturation of V7+ and V4+ T cells to the gut epithelium.

References

• [1] New Insights Into the Regulation of T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity. Front Immunol. 2018 Jul 11;9:1601.