Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBH0LA)

DTT Name Alpha-secretase (ASE)
Gene Name ASE
DTT Type
Literature-reported target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T18204

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
APH-1105 DMT2IWF Alzheimer disease 8A20 Phase 2 [2]
ID1201 DM3LHAX Alzheimer disease 8A20 Phase 2 [3]
APH-1104 DMVQI2A Alzheimer disease 8A20 Phase 1 [4]
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References

1 Alpha-secretase as a therapeutic target. Curr Alzheimer Res. 2007 Sep;4(4):412-7.
2 Alzheimer's disease drug development pipeline: 2021. Alzheimers Dement (N Y). 2021 May 25;7(1):e12179.
3 Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway. Environ Toxicol Pharmacol. 2014 Mar;37(2):513-20.
4 Clinical pipeline report, company report or official report of Aphios