Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBJZ7D)

• DTT Name: HUMAN interleukin-1 beta (IL1B)
• Synonyms: IL1F2; IL-1beta; IL-1 beta; Catabolin
• Gene Name: IL1B
• BioChemical Class: Cytokine: interleukin
• UniProt ID: IL1B_HUMAN
• TTD ID: T98155
• Sequence:
  MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
  FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
  SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
  KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
  SQAENMPVFLGGTKGGQDITDFTMQFVSS
• Function: Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Potent proinflammatory cytokine.
• KEGG Pathway:
  Antifolate resistance (hsa01523)
  MAPK signaling pathway (hsa04010)
  Cytokine-cytokine receptor interaction (hsa04060)
  NF-kappa B signaling pathway (hsa04064)
  Necroptosis (hsa04217)
  Osteoclast differentiation (hsa04380)
  Toll-like receptor signaling pathway (hsa04620)
  NOD-like receptor signaling pathway (hsa04621)
  Cytosolic DNA-sensing pathway (hsa04623)
  C-type lectin receptor signaling pathway (hsa04625)
  Hematopoietic cell lineage (hsa04640)
  IL-17 signaling pathway (hsa04657)
  Th17 cell differentiation (hsa04659)
  TNF signaling pathway (hsa04668)
  Inflammatory mediator regulation of TRP channels (hsa04750)
  Non-alcoholic fatty liver disease (hsa04932)
  AGE-RAGE signaling pathway in diabetic complications (hsa04933)
  Alcoholic liver disease (hsa04936)
  Type I diabetes mellitus (hsa04940)
  Alzheimer disease (hsa05010)
  Prion disease (hsa05020)
  Pathways of neurodegeneration - multiple diseases (hsa05022)
  Pathogenic Escherichia coli infection (hsa05130)
  Shigellosis (hsa05131)
  Salmonella infection (hsa05132)
  Pertussis (hsa05133)
  Legionellosis (hsa05134)
  Yersinia infection (hsa05135)
  Leishmaniasis (hsa05140)
  Chagas disease (hsa05142)
  African trypanosomiasis (hsa05143)
  Malaria (hsa05144)
  Amoebiasis (hsa05146)
  Tuberculosis (hsa05152)
  Measles (hsa05162)
  Human cytomegalovirus infection (hsa05163)
  Influenza A (hsa05164)
  Herpes simplex virus 1 infection (hsa05168)
  Coronavirus disease - COVID-19 (hsa05171)
  Inflammatory bowel disease (hsa05321)
  Rheumatoid arthritis (hsa05323)
  Graft-versus-host disease (hsa05332)
  Lipid and atherosclerosis (hsa05417)
  Fluid shear stress and atherosclerosis (hsa05418)
• Reactome Pathway:
  Pyroptosis (R-HSA-5620971)
  CLEC7A/inflammasome pathway (R-HSA-5660668)
  Interleukin-10 signaling (R-HSA-6783783)
  Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807)
  Interleukin-1 signaling (R-HSA-9020702)
  Purinergic signaling in leishmaniasis infection (R-HSA-9660826)
  Interleukin-1 processing (R-HSA-448706)

References

• [1] ClinicalTrials.gov (NCT04363008) COVID-19 Inflammatory Blood Biomarkers for Clinical Management, Prognosis and Evaluation of Interventions