Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBO2A9)

• DTT Name: Deoxyhypusine synthase (DHPS)
• Synonyms: DHS
• Gene Name: DHPS
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Alkyl aryl transferase
• UniProt ID: DHYS_HUMAN
• TTD ID: T62265
• EC Number: EC 2.5.1.46
• Sequence:
  MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
  RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV
  QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE
  DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS
  LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA
  DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD
  AFMHEKNED
• Function: Catalyzes the NAD-dependent oxidativecleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
• Reactome Pathway: Hypusine synthesis from eIF5A-lysine (R-HSA-204626)
• BioCyc Pathway: MetaCyc:HS01810-MON

Molecular Interaction Atlas (MIA) of This DTT

4 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-Guanidinium-7-Aminoheptane	DM42IY7	Discovery agent	N.A.	Investigative	[1]
N-guanyl-1,7-diaminoheptane	DMBG3ZF	Discovery agent	N.A.	Investigative	[2]
N1-guanyl-1,7-diaminoheptane	DMXE8CB	Discovery agent	N.A.	Investigative	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme w... Bioorg Med Chem. 2007 Sep 15;15(18):6200-7.
• [3] Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture. Biochim Biophys Acta. 1996 Jan 10;1310(1):119-26.