Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBWX8P)

DTT Name	Staphylococcus Manganese transporter C (Stap-coc MntC)
Synonyms	Metal ABC transporter substrate-binding protein; Manganese ABC transporter substrate-binding protein; Manganese ABC transporter substrate-binding lipoprotein; ABC transporter substrate-binding protein; ABC superfamily ATP binding cassette transporter, binding protein
Gene Name	Stap-coc MntC
DTT Type	Clinical trial target	[1]
UniProt ID	W8TNQ9_STAAU
TTD ID	T61547
Sequence	MKKLVPLLLALLLLVAACGTGGKQSSDKSNGKLKVVTTNSILYDMAKNVGGDNVDIHSIV PVGQDPHEYEVKPKDIKKLTDADVILYNGLNLETGNGWFEKALEQAGKSLKDKKVIAVSK DVKPIYLNGEEGNKDKQDPHAWLSLDNGIKYVKTIQQTFIDNDKKHKADYEKQGNKYIAQ LEKLNNDSKDKFNDIPKEQRAMITSEGAFKYFSKQYGITPGYIWEINTEKQGTPEQMRQA IEFVKKHKLKHLLVETSVDKKAMESLSEETKKDIFGEVYTDSIGKEGTKGDSYYKMMKSN IETVHGSMK
Function	A component of Mnt comples, conserved across the staphylococcal species group. Expressed on the cell surface of S. aureus in biofilms generated in in vivo models of infection.
KEGG Pathway	ABC transporters (sams02010 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-06290510	DMUAOFM	Major depressive disorder	6A70.3	Phase 2	[1]
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References

1	ClinicalTrials.gov (NCT01364571) Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years. U.S. National Institutes of Health.