Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTC8YPT)

DTT Name Solute carrier family 38 member 5 (SLC38A5)
Synonyms System N transporter 2; Sodium-coupled neutral amino acid transporter 5; SNAT5; SN2; PP7194; JM24
Gene Name SLC38A5
DTT Type
Literature-reported target
 [1]
UniProt ID
S38A5_HUMAN
TTD ID
T86817
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNA
IMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFG
PAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVL
IILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPS
QGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGA
MFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRA
LQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIF
YLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH
Function
Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.
KEGG Pathway
GABAergic synapse (hsa04727 )
Reactome Pathway
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]histidine DMVUF71 Discovery agent N.A. Investigative [1]
[3H]histidine DMJ5BDQ N. A. N. A. Investigative [1]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name Sodium-coupled neutral amino acid transporter 5 (SLC38A5) DTP Info
Gene Name SLC38A5
2 Approved Drug(s) Transported by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Alanine DMZDN4W Dietary shortage 5B5K Approved [2]
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [2]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1173).
2 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.