General Information of Drug Therapeutic Target (DTT) (ID: TTCAQMW)

DTT Name Inosine-5'-monophosphate dehydrogenase (IMPDH)
Gene Name IMPDH
DTT Type
Successful target
[1]
BioChemical Class
Short-chain dehydrogenases reductase
UniProt ID
NOUNIPROTAC
TTD ID
T28925
KEGG Pathway
Purine metabolism (hsa00230 )
Drug metabolism - other enzymes (hsa00983 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Purine ribonucleoside monophosphate biosynthesis (R-HSA-73817 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enteric-coated mycophenolate sodium DMK659W Transplant rejection NE84 Approved [1]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [2]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
VX-944 DME321B Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
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2 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
IMS DMFACQU Inflammatory bowel disease DD72 Discontinued in Phase 1 [4]
R-1518 DM2J5AO Hepatitis C virus infection 1E51.1 Discontinued in Phase 1 [5]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
EPB-415 DMBLSX3 Hepatitis C virus infection 1E51.1 Investigative [6]
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References

1 Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients. Clin Sci (Lond). 2004 Jul;107(1):63-8.
2 Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
3 Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene. 2005 Sep 1;24(38):5888-96.
4 The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock. 2009 Sep;32(3):258-62.
5 US patent application no. 2010,0092,479, Compositions and methods for treatment of viral diseases.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2625).