Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCG5PE)

DTT Name Thrombopoietin (THPO)
Synonyms Myeloproliferative leukemia virus oncogene ligand; Megakaryocyte growth and development factor; Megakaryocyte colony-stimulating factor; ML; MGDF; C-mpl ligand
Gene Name THPO
DTT Type
Clinical trial target
 [1]
BioChemical Class
EPO/TPO family
UniProt ID
TPO_HUMAN
TTD ID
T99379
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
Jak-STAT signaling pathway (hsa04630 )
Hematopoietic cell lineage (hsa04640 )
Reactome Pathway
Platelet Aggregation (Plug Formation) (R-HSA-76009 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
A157 DMFP4FX Immune thrombocytopenic purpura 3B64.13 IND submitted [2]
BVI-007 DM43GPX Myocardial infarction BA41-BA43 Phase 1 [1]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of Klus Pharma