| DTT Name |
HUMAN histone deacetylase 2 (HDAC2)
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| Synonyms |
HD2 |
| Gene Name |
HDAC2
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| BioChemical Class |
Carbon-nitrogen hydrolase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 3.5.1.98
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| Sequence |
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| Function |
Human protein histone deacetylase 2 interacts with SARS-CoV-2 Nsp5 protein with high significance, which indicates HDAC2 as a potential therapeutic target. |
| KEGG Pathway |
- Cell cycle (hsa04110 )
- Longevity regulating pathway - multiple species (hsa04213 )
- Notch signaling pathway (hsa04330 )
- Neutrophil extracellular trap formation (hsa04613 )
- Thyroid hormone signaling pathway (hsa04919 )
- Huntington disease (hsa05016 )
- Amphetamine addiction (hsa05031 )
- Alcoholism (hsa05034 )
- Human papillomavirus infection (hsa05165 )
- Epstein-Barr virus infection (hsa05169 )
- Pathways in cancer (hsa05200 )
- Transcriptional misregulation in cancer (hsa05202 )
- Viral carcinogenesis (hsa05203 )
- MicroRNAs in cancer (hsa05206 )
- Chronic myeloid leukemia (hsa05220 )
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| Reactome Pathway |
- NOTCH1 Intracellular Domain Regulates Transcription (R-HSA-2122947 )
- Constitutive Signaling by NOTCH1 PEST Domain Mutants (R-HSA-2644606 )
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862 )
- HDACs deacetylate histones (R-HSA-3214815 )
- Notch-HLH transcription pathway (R-HSA-350054 )
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (R-HSA-427389 )
- NoRC negatively regulates rRNA expression (R-HSA-427413 )
- SUMOylation of chromatin organization proteins (R-HSA-4551638 )
- Regulation of TP53 Activity through Acetylation (R-HSA-6804758 )
- RNA Polymerase I Transcription Initiation (R-HSA-73762 )
- Regulation of PTEN gene transcription (R-HSA-8943724 )
- Regulation of MECP2 expression and activity (R-HSA-9022692 )
- MECP2 regulates neuronal receptors and channels (R-HSA-9022699 )
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (R-HSA-9615017 )
- EGR2 and SOX10-mediated initiation of Schwann cell myelination (R-HSA-9619665 )
- Potential therapeutics for SARS (R-HSA-9679191 )
- STAT3 nuclear events downstream of ALK signaling (R-HSA-9701898 )
- Factors involved in megakaryocyte development and platelet production (R-HSA-983231 )
- p75NTR negatively regulates cell cycle via SC1 (R-HSA-193670 )
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