Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCQ21Y)

DTT Name	Methylmalonyl-CoA mutase (MMUT)
Synonyms	Methylmalonyl-CoA isomerase; MUT; MCM
Gene Name	MUT
DTT Type	Successful target	[1]
BioChemical Class	Intramolecular transferases
UniProt ID	MUTA_HUMAN
TTD ID	T15569
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 5.4.99.2
Sequence	MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLI WHTPEGISIKPLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESN KFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLE KMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMK IIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQAGLTIDE FAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTE QDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPK VADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARID SGSEVIVGVNKYQLEKEDAVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTEC AASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSA IKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQ AVDADVHAVGISTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSN VFGPGTRIPKAAVQVLDDIEKCLEKKQQSV
Function	Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.
KEGG Pathway	Valine, leucine and isoleucine degradation (hsa00280 ) Glyoxylate and dicarboxylate metabolism (hsa00630 ) Propanoate metabolism (hsa00640 ) Metabolic pathways (hsa01100 ) Carbon metabolism (hsa01200 )
Reactome Pathway	Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741 )
BioCyc Pathway	MetaCyc:HS07322-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxocobalamin	DMGKV9D	Cerebral edema	8D60.1	Approved	[1]
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1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
mRNA-3704	DME7PBN	Methylmalonic acidemia	5C50.E0	Phase 1/2	[2]
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References

1	Vitamin B12. Nippon Rinsho. 1999 Oct;57(10):2205-10.
2	Clinical pipeline report, company report or official report of Moderna Therapeutics.