Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCS3P1)

DTT Name	Mycobacterium D-alanine-D-alanine ligase A (MycB ddl)
Synonyms	ddlA; D-alanylalanine synthetase A; D-Ala-D-Ala ligase A
Gene Name	MycB ddl
DTT Type	Successful target	[1]
BioChemical Class	Carbon-nitrogen ligase
UniProt ID	DDL_MYCTU
TTD ID	T12187
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 6.3.2.4
Sequence	MSANDRRDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAVGITPAGSWVLTD ANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFPVLHGP YGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLH RQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELEC GVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAAELDVPAKVDDQVAEAIRQ LAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPGFTTISMYPRMWAASGVDYPTLLAT MIETTLARGVGLH
Function	Cell wall formation.
KEGG Pathway	D-Alanine metabolism (mtu00473 ) Peptidoglycan biosynthesis (mtu00550 ) Metabolic pathways (mtu01100 ) Vancomycin resistance (mtu01502 )
BioCyc Pathway	MetaCyc:G185E-7236-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase ... J Biol Chem. 2004 Oct 29;279(44):46143-52.