Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCS8WB)

DTT Name Plasmodium Choline transporter (Malaria CT)
Synonyms Glycerol-3-phosphate 1-O-acyltransferase
Gene Name Malaria CT
DTT Type
Literature-reported target
 [1]
UniProt ID
Q8I5S7_PLAF7
TTD ID
T83794
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.3.1.15
Sequence
MPDFYFLIRWLCKVIVKSVFRDVNVINPENVPLYGSVIFVGNHNNQFIDACVLIANIPRQ
VKFIVAEKSMRRAVIGKLASVIGCISVKRPQDLKFKGIGHICWNEGDVKITGINTRFRLD
VQIGDKLLIQNKMFPVVKIESETELLIQEVINIECEDKMNGVPFKIIPKINQTEVYNLVT
NSLKNGDTIGIFPEGGSHDRTNLLPLKPGVAIMTLCALADGIEDVSIIPVGLSYSKLYQL
QGCATLFYGNAIIISQDLCKEYNNNNREAISKLLSKIEEGMRSCMLTSKDHETSRCIELC
VSLYTPERMTISKNKIYNNLQLFCKMFWKFGNSKVIENLSYELKCYEKLLQANKIKDDEV
WMLKQSTSAATLKFIEHICTFIFCVIFGMTFSLLWLPLVLISIYLAERHRKAALRNSTIK
IQGGDVVSSYKVLVLIVLLPTFNIVYGLLFSIYLYHSWLKRILFVFLSMCILPICYYINL
NYAVQIPSLLRQMKILLKVICGKINVWRDNERELISTRHELQLKVRDLVSTLGPDVSDDF
LEQLYRNIPKFVVDVDTKRLIRGKDEFLPILQRSQLEYKEEIL
Function Mediates the delivery of these compounds to the intracellular parasite
KEGG Pathway
Glycerolipid metabolism (pfa00561 )
Glycerophospholipid metabolism (pfa00564 )
Metabolic pathways (pfa01100 )
Biosynthesis of secondary metabolites (pfa01110 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
G-25 DMADOK6 Discovery agent N.A. Investigative [1]
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References

1 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.