Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCVQYE)

DTT Name	Dynactin-associated protein (DYNAP)
Synonyms	Full; C18orf26
Gene Name	DYNAP
DTT Type	Literature-reported target	[1]
UniProt ID	DYNAP_HUMAN
TTD ID	T12623
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVADIKGNEQIEKYSWREACDTGSSRMDRKHGKYILNVEHSENQPPITHPNDQEAHSSIC WCLPSNDITSDVSPNLTGVCVNPGILAHSRCLQSESCNTQVKEYCRNDWSMWKVFLACLL ACVIMTAIGVLIICLVNNKGSANSSIVIQLSTNDGECVTVKPGTPSPACPPTMTTTSTVP ASTATESTTSTATAATTSTEPITVAPTDHL
Function	Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.

References

1	A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of ... Mol Cancer Ther. 2010 Nov;9(11):2934-42.