Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTD3TZ2)

DTT Name	HUMAN proteinase activated receptor 2 (PAR2)
Synonyms	Thrombin receptor-like 1; Proteinase-activated receptor-2; Proteinase-activated receptor 2; Protease activated receptor 2; PAR-2; GPR11; G-protein coupled receptor 11; Coagulation factor II receptor-like 1
Gene Name	F2RL1
BioChemical Class	GPCR rhodopsin
UniProt ID	PAR2_HUMAN
TTD ID	T01007
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFS VDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALA DLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNP MGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMF NYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICF TPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALL CRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
Function	Human protein F2R like trypsin receptor 1 interacts with SARS-CoV-2 Orf9c protein with high significance, which indicates F2RL1 as a potential therapeutic target.
KEGG Pathway	Neuroactive ligand-receptor interaction (hsa04080 ) Inflammatory mediator regulation of TRP channels (hsa04750 ) African trypanosomiasis (hsa05143 )
Reactome Pathway	G alpha (q) signalling events (R-HSA-416476 ) Peptide ligand-binding receptors (R-HSA-375276 )

References

1	A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.