Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTD81N3)

DTT Name Small ribosomal subunit protein eS12 (RPS12)
Synonyms 40S ribosomal protein S12
Gene Name RPS12
DTT Type
Literature-reported target
 [1]
BioChemical Class
Ribosomal protein
UniProt ID
RS12_HUMAN
TTD ID
T89215
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPM
YVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQA
KDVIEEYFKCKK
Function
A component of the 40S ribosome subunit. Ribosome, the organelle that catalyzes protein synthesis, consists of a small 40S subunit and a large 60S subunit. Increased expression in colorectal cancers compared to matched normal colonic mucosa.
KEGG Pathway
Ribosome (hsa03010 )
Coronavirus disease - COVID-19 (hsa05171 )
Reactome Pathway
Peptide chain elongation (R-HSA-156902 )
SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339 )
Viral mRNA Translation (R-HSA-192823 )
Selenocysteine synthesis (R-HSA-2408557 )
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 )
Translation initiation complex formation (R-HSA-72649 )
Formation of a pool of free 40S subunits (R-HSA-72689 )
Formation of the ternary complex, and subsequently, the 43S complex (R-HSA-72695 )
Ribosomal scanning and start codon recognition (R-HSA-72702 )
GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 )
Eukaryotic Translation Termination (R-HSA-72764 )
Regulation of expression of SLITs and ROBOs (R-HSA-9010553 )
Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012 )
SARS-CoV-2 modulates host translation machinery (R-HSA-9754678 )
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956 )
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957 )
L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )

References

1 Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. Br J Cancer. 2002 Jan 21;86(2):274-81.