Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDBOI7)

DTT Name HUAMN alpha-1 adrenergic receptor (ADRA1)
Synonyms Alpha-1 adrenoreceptor
Gene Name ADRA1A
BioChemical Class
Adrenergic receptor subfamily
UniProt ID
ADA1A_HUMAN ; ADA1B_HUMAN ; ADA1D_HUMAN
TTD ID
T00216
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
KEGG Pathway
Calcium signaling pathway (hsa04020 )
cGMP-PKG signaling pathway (hsa04022 )
Neuroactive ligand-receptor interaction (hsa04080 )
AMPK signaling pathway (hsa04152 )
Adrenergic signaling in cardiomyocytes (hsa04261 )
Vascular smooth muscle contraction (hsa04270 )
Salivary secretion (hsa04970 )
Reactome Pathway
G alpha (q) signalling events (R-HSA-416476 )
G alpha (12/13) signalling events (R-HSA-416482 )
Adrenoceptors (R-HSA-390696 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [1]
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References

1 Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus. J Am Coll Cardiol. 2003 Jan 15;41(2):340-5.