Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDJBV3)

• DTT Name: Tryptophan hydroxylase (TPH)
• Synonyms: Tryptophan 5-monooxygenase; TPH
• Gene Name: TPH1
• DTT Type: Successful target; [1]
• BioChemical Class: Paired donor oxygen oxidoreductase
• UniProt ID: TPH1_HUMAN ; TPH2_HUMAN
• TTD ID: T51593
• Sequence:
  MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
  EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
  RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
  LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
  FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
  SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
  KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
  MNELQHDLDVVSDALAKVSRKPSI
• Function: Responsible for addition of the -HO group (hydroxylation) to the 5 position to form the amino acid 5-hydroxytryptophan (5-HTP), which is the initial and rate-limiting step in the synthesis of the neurotransmitter serotonin.
• KEGG Pathway:
  Tryptophan metabolism (hsa00380)
  Folate biosynthesis (hsa00790)
  Metabolic pathways (hsa01100)
  Serotonergic synapse (hsa04726)
• Reactome Pathway:
  NGF-stimulated transcription (R-HSA-9031628)
  Serotonin and melatonin biosynthesis (R-HSA-209931)
• BioCyc Pathway: MetaCyc:HS05250-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Telotristat ethyl	DMDIYFZ	Carcinoid syndrome	5B10	Approved	[1]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.