Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDNM9W)

DTT Name	Follistatin (FST)
Synonyms	FST; FS; Activinbinding protein
Gene Name	FST
DTT Type	Literature-reported target	[1]
UniProt ID	FST_HUMAN
TTD ID	T43901
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA ACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW
Function	Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
KEGG Pathway	TGF-beta signaling pathway (hsa04350 )
Reactome Pathway	Antagonism of Activin by Follistatin (R-HSA-2473224 )

References

1	Role of activin, follistatin, and inhibin in the regulation of kiss-1 gene expression in hypothalamic cell models. Biol Reprod. 2019 Jun 5. pii: ioz094.