Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTEARWC)

• DTT Name: Solute carrier family 38 member 7 (SLC38A7)
• Synonyms: SNAT7
• Gene Name: SLC38A7
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Amino acid/polyamine transporter 2 family
• UniProt ID: S38A7_HUMAN
• TTD ID: T93337
• Sequence:
  MAQVSINNDYSEWDLSTDAGERARLLQSPCVDTAPKSEWEASPGGLDRGTTSTLGAIFIV
  VNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQASNERTYQEVVW
  AVCGKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGASGPWYTDRKFTI
  SLTAFLFILPLSIPREIGFQKYASFLSVVGTWYVTAIVIIKYIWPDKEMTPGNILTRPAS
  WMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVVTAAMVIALAVYMGTGICGFL
  TFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYQGVPVE
  EDVGRERRRRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFIFVFPGLCLIQAKLS
  EMEEVKPASWWVLVSYGVLLVTLGAFIFGQTTANAIFVDLLA
• Function: Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7) DTP Info
• Gene Name: SLC38A7

2 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[2]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[3]

References

• [1] SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3602-E3611.
• [2] Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. Clin Pharmacol Ther. 2019 Jan 16.
• [3] Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.