Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTF9OQ6)

DTT Name Branched-chain-amino-acid transaminase 2 (BCAT2)
Synonyms Placental protein 18; PP18; ECA39 protein; Branched-chain amino acid aminotransferase; BCAT2; BCAT(m); BCAT
Gene Name BCAT2
DTT Type
Literature-reported target
 [1]
BioChemical Class
Transaminase
UniProt ID
BCAT2_HUMAN
TTD ID
T94788
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.6.1.42
Sequence
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
Function Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
KEGG Pathway
Valine, leucine and isoleucine degradation (hsa00280 )
Valine, leucine and isoleucine biosynthesis (hsa00290 )
Pantothenate and CoA biosynthesis (hsa00770 )
Metabolic pathways (hsa01100 )
Biosynthesis of antibiotics (hsa01130 )
2-Oxocarboxylic acid metabolism (hsa01210 )
Biosynthesis of amino acids (hsa01230 )
Reactome Pathway
Branched-chain amino acid catabolism (R-HSA-70895 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
5 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alpha-ketoisovalerate DMBZTS5 Discovery agent N.A. Investigative [1]
N'-(phenylsulfonyl)benzofuran-2-carbohydrazide DMJO3B1 Discovery agent N.A. Investigative [2]
N'-(phenylsulfonyl)quinoline-6-carbohydrazide DMQETUY Discovery agent N.A. Investigative [2]
N-[O-Phosphono-Pyridoxyl]-Isoleucine DM6EICU Discovery agent N.A. Investigative [1]
Pyridoxamine-5'-Phosphate DMQ6POC Discovery agent N.A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40.