Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFBUWA)

DTT Name	Pantothenate kinase 3 (PANK3)
Synonyms	hPanK3; Pantothenic acid kinase 3
Gene Name	PANK3
DTT Type	Clinical trial target	[1]
BioChemical Class	Kinase
UniProt ID	PANK3_HUMAN
TTD ID	T63183
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.7.1.33
Sequence	MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGS TGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYK FEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLD DPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASK GDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNN IGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAV GALLGLPNFS
Function	Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269\|PubMed:17631502, ECO:0000269\|PubMed:20797618, ECO:0000269\|PubMed:27555321, ECO:0000269\|PubMed:30927326}.
KEGG Pathway	79646 (hsa )
Reactome Pathway	( ) (R-HSA-196783 )
BioCyc Pathway	MetaCyc:HS04372-MONOMER

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BBP-671	DMR9XMZ	Methylmalonic acidemia	5C50.E0	Phase 1	[1]
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References

1	Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia. J Inherit Metab Dis. 2023 Jan;46(1):28-42.