Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFQVUT)

DTT Name	NADPH oxidase (NOX)
Gene Name	NOX
DTT Type	Clinical trial target	[1]
UniProt ID	NOUNIPROTAC
TTD ID	T32137
Function	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
KEGG Pathway	HIF-1 signaling pathway (hsa04066 ) Phagosome (hsa04145 ) Osteoclast differentiation (hsa04380 ) Leukocyte transendothelial migration (hsa04670 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GKT-137831	DMOVB3Y	Fibrosis	GA14-GC01	Phase 2	[1]
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1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SINOMENINE	DMYP3KI	Arthritis	FA20	Discontinued in Phase 2	[2]
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References

1	Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) in Experimental Liver Fibrosis: GKT137831 as a Novel Potential Therapeutic Agent. Hepatology. 2012 December; 56(6): 2316-2327.
2	Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2007 Sep 19;4:23.