Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFRES8)

DTT Name	Regulator of G-protein signaling 16 (RGS16)
Synonyms	hRGS-r; Retinally abundant regulator of G-protein signaling; Retinal-specific RGS; RGSR; RGS-r; A28-RGS14P
Gene Name	RGS16
DTT Type	Patented-recorded target	[1]
UniProt ID	RGS16_HUMAN
TTD ID	T52888
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVL GWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEE FICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDL AAQASAASATLSSCSLDEPSHT
Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. Regulates G protein-coupled receptor signaling cascades.
Reactome Pathway	G alpha (i) signalling events (R-HSA-418594 ) G alpha (z) signalling events (R-HSA-418597 ) G alpha (q) signalling events (R-HSA-416476 )

References

1	RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells. Genes Cancer. 2014 Nov;5(11-12):420-35.