Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGCH11)

DTT Name	Fibroblast growth factor 19 (FGF19)
Synonyms	FGF-19
Gene Name	FGF19
DTT Type	Clinical trial target	[1]
BioChemical Class	Heparin-binding growth factors family
UniProt ID	FGF19_HUMAN
TTD ID	T63244
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRSGCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFL RIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDC AFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLR GHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK
Function	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269\|PubMed:12815072, ECO:0000269\|PubMed:16597617, ECO:0000269\|PubMed:17623664, ECO:0000269\|PubMed:19085950}.
KEGG Pathway	9965 (hsa )
Reactome Pathway	( ) (R-HSA-109704 ) (R-HSA-1257604 ) (R-HSA-1307965 ) (R-HSA-190322 ) (R-HSA-2219530 ) (R-HSA-5654228 ) (R-HSA-5654712 ) (R-HSA-5654719 ) (R-HSA-5654720 ) (R-HSA-5654733 ) (R-HSA-5673001 ) (R-HSA-6811558 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldafermin	DM5ITEZ	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[1]
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References

1	Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis. Gastroenterology. 2021 Jan;160(1):219-231.e1.