Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGTNSL)

• DTT Name: WNT1-inducible-signaling pathway protein 1 (WISP1)
• Synonyms: Wnt-1-induced secreted protein; WISP1; WISP-1; CCN family member 4
• Gene Name: WISP1
• DTT Type: Literature-reported target; [1]
• UniProt ID: WISP1_HUMAN
• TTD ID: T71859
• Sequence:
  MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP
  RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVG
  VGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC
  EQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISN
  VNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKY
  CGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYP
  DFSEIAN
• Function: Downstream regulator in the Wnt/Frizzled-signalingpathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skinand melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
• KEGG Pathway: Wnt signaling pathway (hsa04310)

References

• [1] The role of CCN4/WISP-1 in the cancerous phenotype. Cancer Manag Res. 2018 Aug 27;10:2893-2903.