Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGX0HR)

DTT Name Bacterial DNA ligase (Bact ligA)
Synonyms ligA; Polydeoxyribonucleotide synthase [NAD+]; NAD+-dependent DNA ligase
Gene Name Bact ligA
DTT Type
Literature-reported target
 [1]
BioChemical Class
Phosphoric ester ligase
UniProt ID
DNLJ_ECOLI
TTD ID
T70310
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 6.5.1.2
Sequence
MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQ
RVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKNNEKVTWCCELKLDGLA
VSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAG
FEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHL
GRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQL
GFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHN
ADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEG
EAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAG
KLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEA
ASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIVINAEEIDSPFAG
KTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVI
DEAEMLRLLGS
Function
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
KEGG Pathway
DNA replication (ecj03030 )
Base excision repair (ecj03410 )
Nucleotide excision repair (ecj03420 )
Mismatch repair (ecj03430 )
BioCyc Pathway
MetaCyc:EG10534-MON
EcoCyc:EG10534-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
5 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(2-hydroxyphenyl)(4-hydroxyphenyl)methanone DMEZNXS Discovery agent N.A. Investigative [1]
2,3-dioxoindoline-7-carboxylic acid DM8C43L Discovery agent N.A. Investigative [1]
3-amino-2-(benzylideneamino)-5-mercaptophenol DMF3DBE Discovery agent N.A. Investigative [1]
5-(methylthio)thiophene-2-carboxylic acid DMYLIX9 Discovery agent N.A. Investigative [1]
7-(4-methoxyphenyl)pteridine-2,4-diol DMLIYUJ Discovery agent N.A. Investigative [1]
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References

1 Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62.