Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTH6MBO)

DTT Name	dUTP pyrophosphatase (DUT)
Synonyms	Deoxyuridine 5' triphosphate nucleotidohydrolase, mitochondrial; DUT
Gene Name	DUT
DTT Type	Clinical trial target	[1]
BioChemical Class	Acid anhydrides hydrolase
UniProt ID	DUT_HUMAN
TTD ID	T39054
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.6.1.23
Sequence	MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE RGSGGFGSTGKN
Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. {ECO:0000269\|PubMed:8805593}.
KEGG Pathway	Pyrimidine metabolism (hsa00240 ) Drug metabolism - other enzymes (hsa00983 ) Metabolic pathways (hsa01100 ) Nucleotide metabolism (hsa01232 )
Reactome Pathway	Interconversion of nucleotide di- and triphosphates (R-HSA-499943 )
BioCyc Pathway	MetaCyc:HS05235-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TAS-114	DM3D52L	Non-small-cell lung cancer	2C25.Y	Phase 2	[1]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)