| DTT Name |
HUMAN C-C chemokine receptor 5 (CCR5)
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| Synonyms |
HIV-1 fusion coreceptor; HIV-1 fusion co-receptor; Chemokine receptor CCR5; CMKBR5; CHEMR13; CD195 antigen; CD195; CCR-5; CC-CKR-5; C-C CKR-5 |
| Gene Name |
CCR5
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| BioChemical Class |
GPCR rhodopsin
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| Sequence |
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| Function |
May play a role in the control of granulocytic lineage proliferation or differentiation. Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
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| KEGG Pathway |
- Viral life cycle - HIV-1 (hsa03250 )
- Cytokine-cytokine receptor interaction (hsa04060 )
- Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
- Chemokine signaling pathway (hsa04062 )
- Endocytosis (hsa04144 )
- Toxoplasmosis (hsa05145 )
- Human cytomegalovirus infection (hsa05163 )
- Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
- Human immunodeficiency virus 1 infection (hsa05170 )
- Viral carcinogenesis (hsa05203 )
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| Reactome Pathway |
- Chemokine receptors bind chemokines (R-HSA-380108 )
- G alpha (i) signalling events (R-HSA-418594 )
- Interleukin-10 signaling (R-HSA-6783783 )
- Binding and entry of HIV virion (R-HSA-173107 )
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