Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHB48R)

DTT Name	Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ)
Synonyms	pdxJ; Pyridoxine 5'-phosphate synthase; PNP synthase
Gene Name	Bact pdxJ
DTT Type	Literature-reported target	[1]
UniProt ID	PDXJ_ECOLI
TTD ID	T51284
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.6.99.2
Sequence	MAELLLGVNIDHIATLRNARGTAYPDPVQAAFIAEQAGADGITVHLREDRRHITDRDVRI LRQTLDTRMNLEMAVTEEMLAIAVETKPHFCCLVPEKRQEVTTEGGLDVAGQRDKMRDAC KRLADAGIQVSLFIDADEEQIKAAAEVGAPFIEIHTGCYADAKTDAEQAQELARIAKAAT FAASLGLKVNAGHGLTYHNVKAIAAIPEMHELNIGHAIIGRAVMTGLKDAVAEMKRLMLE ARG
Function	Catalyzes the condensation of 1-deoxy-d-xylulose-5- phosphate (dxp) and 1-amino-3-(phosphohydroxy)propan-2-one to form pyridoxine 5'-phosphate (pnp).
KEGG Pathway	Vitamin B6 metabolism (ecj00750 ) Metabolic pathways (ecj01100 ) Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway	MetaCyc:PDXJ-MON EcoCyc:PDXJ-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-Deoxy-D-Xylulose-5-Phosphate	DMCSPU4	Discovery agent	N.A.	Investigative	[1]
3-Phosphoglycerol	DM9BDV2	Discovery agent	N.A.	Investigative	[1]
Pyridoxine-5'-Phosphate	DMFUNL1	Discovery agent	N.A.	Investigative	[1]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.