Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHJWVK)

• DTT Name: Mycobacterium Bisphosphoglycerate phosphoglycerate mutase (MycB gpmI)
• Synonyms: gpmI; Phosphoglyceromutase; Phosphoglycerate mutase; IPGM; BPG-independent PGAM
• Gene Name: MycB gpmI
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Intramolecular transferases
• UniProt ID: GPMI_MYCGE
• TTD ID: T54526
• Sequence:
  MHKKVLLAILDGYGISNAIYGNAVQNANTPMLDELINSYPCVLLDASGEAVGLPMGQIGN
  SEVGHLNIGAGRVVYTGLSLINQHIKDRSFFANKAFLKTIEHVEKNHSKIHLIGLFSNGG
  VHSHNEHLLALIELFSKHAKVVLHLFGDGRDVAPCSLKQDLEKLMIFLKNYPNVVIGTIG
  GRYYGMDRDQRWDREMIAYKALLGVSKNKFNDPIGYIETQYQNQITDEFIYPAINANLNS
  DQFALNNNDGVIFFNFRPDRARQMSHLIFNSNYYNYQPELKRKENLFFVTMMNYEGIVPS
  EFAFPPQTIKNSLGEVIANNNLKQLRIAETEKYAHVTFFFDGGFEVNLSNETKTLIPSLK
  VATYDLAPEMSCKAITDALLEKLNNFDFTVLNFANPDMVGHTGNYQACIKALEALDVQIK
  RIVDFCKANQITMFLTADHGNAEVMIDNNNNPVTKHTINPVPFVCTDKNVNFNQTGILAN
  IAPTILEYLNLSKPKEMTAKSLLKNNN
• Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
• KEGG Pathway:
  Glycolysis / Gluconeogenesis (mge00010)
  Glycine, serine and threonine metabolism (mge00260)
  Methane metabolism (mge00680)
  Metabolic pathways (mge01100)
  Biosynthesis of secondary metabolites (mge01110)
  Microbial metabolism in diverse environments (mge01120)
  Biosynthesis of antibiotics (mge01130)
  Carbon metabolism (mge01200)
  Biosynthesis of amino acids (mge01230)

Molecular Interaction Atlas (MIA) of This DTT

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Phosphoglyceric Acid	DMX6GH5	Discovery agent	N.A.	Investigative	[1]
3-Phosphoglyceric Acid	DMIK9VO	Discovery agent	N.A.	Investigative	[1]
Clorsulon	DMU6FOG	Discovery agent	N.A.	Investigative	[2]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Modes of action of anthelmintic drugs. Vet J. 1997 Jul;154(1):11-34.