Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHVBOC)

DTT Name	Gamma-aminobutyric acid transporter 4 (SLC6A11)
Synonyms	Sodium- and chloride-dependent GABA transporter 4; Slc6a11; GAT4; GABA transporter 4
Gene Name	Slc6a11
DTT Type	Literature-reported target	[1]
BioChemical Class	Neurotransmitter:sodium symporter
UniProt ID	S6A11_HUMAN
TTD ID	T14252
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
Function	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.
KEGG Pathway	Synaptic vesicle cycle (hsa04721 ) GABAergic synapse (hsa04727 )
Reactome Pathway	Creatine metabolism (R-HSA-71288 ) Reuptake of GABA (R-HSA-888593 ) Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SNAP-5114	DMFM19S	Discovery agent	N.A.	Investigative	[1]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Sodium- and chloride-dependent GABA transporter 3 (SLC6A11) DTP Info

Gene Name

SLC6A11

1 Investigative Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-Alanine	DMC64EI	Discovery agent	N.A.	Investigative	[2]
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References

1	GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407.
2	Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7.