Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTICX3S)

DTT Name Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)
Synonyms UDP-N-acetylglucosamine enolpyruvyl transferase; UDP-GlcNAcenolpyruvyl transferase; MurA protein; MurA; Enoylpyruvate transferase; EPT
Gene Name Bact murA
DTT Type
Successful target
 [1]
BioChemical Class
Alkyl aryl transferase
UniProt ID
MURA_ECOLI
TTD ID
T24634
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
Function Cell wall formation. Adds enolpyruvyl to UDP-n- acetylglucosamine. Target for the antibiotic phosphomycin.
KEGG Pathway
Amino sugar and nucleotide sugar metabolism (ecj00520 )
Peptidoglycan biosynthesis (ecj00550 )
Metabolic pathways (ecj01100 )
Biosynthesis of nucleotide sugars (ecj01250 )
BioCyc Pathway
MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-MON
EcoCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fosfomycin DMVGPMX Bacterial infection 1A00-1C4Z Approved [1]
------------------------------------------------------------------------------------
9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aminomethylcyclohexane DMNX9FC Discovery agent N.A. Investigative [2]
CNICIN DMEVM0J Discovery agent N.A. Investigative [3]
Cyclohexylammonium Ion DMYQH2N Discovery agent N.A. Investigative [2]
CYNAROPICRIN DMG0PHU Discovery agent N.A. Investigative [3]
EUPATORIOPICRIN DM068CY Discovery agent N.A. Investigative [3]
L-Iso-Aspartate DM26AB4 Discovery agent N.A. Investigative [2]
RWJ-140998 DMP7SI9 Gram-positive bacterial infection 1B74-1G40 Investigative [4]
RWJ-3981 DMBVLCQ Gram-positive bacterial infection 1B74-1G40 Investigative [4]
Uridine-Diphosphate-N-Acetylglucosamine DMEQSTP Discovery agent N.A. Investigative [5]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 Investigative Drug(s)

References

1 Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.
4 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
5 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.