| DTT Name |
HUMAN beta adrenergic receptor (BAR)
|
| Synonyms |
Beta adrenoreceptor |
| Gene Name |
ADRB1
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| BioChemical Class |
G-protein coupled receptor 1 family
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| UniProt ID |
ADRB1_HUMAN
; ADRB2_HUMAN
; ADRB3_HUMAN
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| TTD ID |
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| 3D Structure |
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| Sequence |
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
|
| Function |
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors.
|
| KEGG Pathway |
- Calcium signaling pathway (hsa04020 )
- cGMP-PKG signaling pathway (hsa04022 )
- cAMP signaling pathway (hsa04024 )
- Neuroactive ligand-receptor interaction (hsa04080 )
- Adrenergic signaling in cardiomyocytes (hsa04261 )
- Gap junction (hsa04540 )
- Regulation of lipolysis in adipocytes (hsa04923 )
- Renin secretion (hsa04924 )
- Salivary secretion (hsa04970 )
- Chemical carcinogenesis - receptor activation (hsa05207 )
- Dilated cardiomyopathy (hsa05414 )
|
| Reactome Pathway |
- G alpha (s) signalling events (R-HSA-418555 )
- ADORA2B mediated anti-inflammatory cytokines production (R-HSA-9660821 )
- Adrenoceptors (R-HSA-390696 )
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