Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJBPN3)

• DTT Name: Biliverdin reductase A (BLVRA)
• Synonyms: Biliverdin-IX alpha-reductase; BVR A; BVR; BLVRA; BLVR
• Gene Name: BLVRA
• DTT Type: Successful target; [1]
• BioChemical Class: CH-CH donor oxidoreductase
• UniProt ID: BIEA_HUMAN
• TTD ID: T37046
• EC Number: EC 1.3.1.24
• Sequence:
  MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
  DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
  LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
  GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
  VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
• Function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
• KEGG Pathway: Porphyrin and chlorophyll metabolism (hsa00860)
• Reactome Pathway:
  Cytoprotection by HMOX1 (R-HSA-9707564)
  Heme degradation (R-HSA-189483)
• BioCyc Pathway: MetaCyc:HS02928-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[2]

References

• [1] Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal... Toxicol Appl Pharmacol. 2008 Oct 15;232(2):327-36.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.