Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJL8VG)

• DTT Name: Corticosteroid-binding globulin (SERPINA6)
• Synonyms: Transcortin; SERPINA6; CBG
• Gene Name: SERPINA6
• DTT Type: Successful target; [1]
• BioChemical Class: Serpin protein
• UniProt ID: CBG_HUMAN
• TTD ID: T88452
• Sequence:
  MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPK
  KNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSD
  TSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQG
  KIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTI
  SYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLY
  IPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDT
  AGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
• Function: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
• Reactome Pathway: Glucocorticoid biosynthesis (R-HSA-194002)

Molecular Interaction Atlas (MIA) of This DTT

3 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alclometasone	DMAE84F	Exanthem		Approved	[1]
Ciclesonide	DM2NA4K	Allergic rhinitis	CA08.0	Approved	[2]
Paramethasone	DM6PR40	Inflammation	1A00-CA43.1	Approved	[2]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
I-vation	DM0OYLQ	Diabetic retinopathy	9B71.0	Phase 2	[3]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Asthma	CA23	Nasal and bronchial airway	3.29E-04	-0.2	-0.2

References

• [1] The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2.
• [2] Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Metab. 2000 Jan;85(1):361-7.
• [3] Cortisol binding in rat skeletal muscle. J Biol Chem. 1975 Feb 25;250(4):1207-11.