Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJOW1I)

• DTT Name: Mannoside acetylglucosaminyltransferase 2 (MGAT2)
• Synonyms: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; Beta-1,2-N-acetylglucosaminyltransferase II; Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
• Gene Name: MGAT2
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Glycosyltransferases
• UniProt ID: MGAT2_HUMAN
• TTD ID: T67812
• EC Number: EC 2.4.1.143
• Sequence:
  MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
  AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
  VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
  IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
  VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
  YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
  FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
  AISPPRKNGGWGDIRDHELCKSYRRLQ
• Function: Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Plays an essential role in protein N-glycosylation.
• KEGG Pathway:
  N-Glycan biosynthesis (hsa00510)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  Maturation of spike protein (R-HSA-9694548)
  Reactions specific to the complex N-glycan synthesis pathway (R-HSA-975578)
  Defective MGAT2 causes CDG-2a (R-HSA-4793952)
• BioCyc Pathway: MetaCyc:HS09725-MON

Molecular Interaction Atlas (MIA) of This DTT

6 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bicyclic pyrimidine derivative 1	DMAJ74C	N. A.	N. A.	Patented	[1]
Dihydropyrimidinone derivative 3	DMA1S6Q	N. A.	N. A.	Patented	[1]
Dihydropyrimidinone derivative 4	DMNEKOZ	N. A.	N. A.	Patented	[1]
N-containing heterocyclic derivative 1	DM6TMXL	N. A.	N. A.	Patented	[1]
Phenylmethanesulfonamide derivative 1	DM1BIY4	N. A.	N. A.	Patented	[1]
Pyrimidine-4(3H)-one derivative 1	DMT6O1N	N. A.	N. A.	Patented	[1]

References

• [1] Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.