Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKGV26)

• DTT Name: Hepatoma-derived growth factor (HDGF)
• Synonyms: High-mobility group protein 1-like 2; High mobility group protein 1-like 2; HMG1L2; HMG-1L2
• Gene Name: HDGF
• DTT Type: Literature-reported target; [1]
• UniProt ID: HDGF_HUMAN
• TTD ID: T84341
• Sequence:
  MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGP
  KDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAE
  GDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEK
  EAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL
• Function: Acts as a transcriptional repressor. Heparin-binding protein, with mitogenic activity for fibroblasts.
• Reactome Pathway: XBP1(S) activates chaperone genes (R-HSA-381038)

References

• [1] Hepatoma derived growth factor is a nuclear targeted mitogen. Curr Drug Targets. 2003 Jul;4(5):367-71.