Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKSV48)

DTT Name	Claudin-6 (CLDN6)
Synonyms	Skullin
Gene Name	CLDN6
DTT Type	Clinical trial target	[1]
UniProt ID	CLD6_HUMAN
TTD ID	T63166
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV
Function	Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269\|PubMed:17804490, ECO:0000269\|PubMed:20375010}.
KEGG Pathway	9074 (hsa )
Reactome Pathway	( ) (R-HSA-420029 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 794	DMS22QR	Aggressive cancer	2A00-2F9Z	Phase 1	[1]
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References

1	ClinicalTrials.gov (NCT05317078) Phase 1 First-In-Human Study to Explore the Safety, Tolerability, and Pharmacokinetics of AMG 794 in Participants With Claudin 6-positive Advanced/Metastatic Non-small Cell Lung Cancer, Epithelial Ovarian Cancer, and Other Malignant Solid Tumor Indications. U.S.National Institutes of Health.