Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKYZA9)

• DTT Name: Gastric triacylglycerol lipase (LIPF)
• Synonyms: Gastric lipase; GL
• Gene Name: LIPF
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Carboxylic ester hydrolase
• UniProt ID: LIPG_HUMAN
• TTD ID: T49064
• EC Number: EC 3.1.1.3
• Sequence:
  MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILE
  VNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRG
  NTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFI
  AFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQF
  LATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKS
  GKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPN
  LIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK
• Function: An acidic lipase secreted by the gastric chief cells in the fundic mucosa in the stomach. Makes up 30% of lipid hydrolysis occurring during digestion in the human adult,
• KEGG Pathway:
  Glycerolipid metabolism (hsa00561)
  Metabolic pathways (hsa01100)
  Fat digestion and absorption (hsa04975)
• Reactome Pathway: Digestion of dietary lipid (R-HSA-192456)

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cetilistat	DMWAHTN	Diabetic complication	5A2Y	Phase 3	[1]

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[2]
Undecyl-Phosphinic Acid Butyl Ester	DMD9KEB	Discovery agent	N.A.	Investigative	[3]

References

• [1] Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.