Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLDRGX)

• DTT Name: G1/S-specific cyclin-E2 (CCNE2)
• Synonyms: G1/Sspecific cyclinE2
• Gene Name: CCNE2
• DTT Type: Literature-reported target; [1]
• UniProt ID: CCNE2_HUMAN
• TTD ID: T19027
• Sequence:
  MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP
  VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK
  ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI
  NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP
  VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA
  LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH
  TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH
• Function: Essential for the control of the cell cycle at the late G1 and early S phase.
• KEGG Pathway:
  Cell cycle (hsa04110)
  Oocyte meiosis (hsa04114)
  p53 signaling pathway (hsa04115)
  PI3K-Akt signaling pathway (hsa04151)
  Cellular senescence (hsa04218)
  Cushing syndrome (hsa04934)
  Hepatitis B (hsa05161)
  Measles (hsa05162)
  Human papillomavirus infection (hsa05165)
  Human T-cell leukemia virus 1 infection (hsa05166)
  Epstein-Barr virus infection (hsa05169)
  Pathways in cancer (hsa05200)
  Viral carcinogenesis (hsa05203)
  MicroRNAs in cancer (hsa05206)
  Prostate cancer (hsa05215)
  Small cell lung cancer (hsa05222)
  Gastric cancer (hsa05226)
• Reactome Pathway:
  SCF(Skp2)-mediated degradation of p27/p21 (R-HSA-187577)
  DNA Damage/Telomere Stress Induced Senescence (R-HSA-2559586)
  Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)
  TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (R-HSA-6804116)
  CDK-mediated phosphorylation and removal of Cdc6 (R-HSA-69017)
  Phosphorylation of proteins involved in G1/S transition by active Cyclin E (R-HSA-69200)
  Cyclin E associated events during G1/S transition (R-HSA-69202)
  Cyclin D associated events in G1 (R-HSA-69231)
  p53-Dependent G1 DNA Damage Response (R-HSA-69563)
  Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (R-HSA-9661069)
  G0 and Early G1 (R-HSA-1538133)

References

• [1] Cyclin D1 and cyclin E2 are differentially expressed in gastric cancer. Med Oncol. 2016 May;33(5):40.