Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLFGBV)

DTT Name Bacterial 23S ribosomal RNA (Bact 23S rRNA)
Synonyms RrnL; Plastid 23S rRNA
Gene Name Bact 23S rRNA
DTT Type
Successful target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T88338

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
7 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [2]
Lefamulin DME6G97 Community-acquired pneumonia CA40.Z Approved [3]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [1]
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [4]
Macrolides DM3BS97 Bacterial infection 1A00-1C4Z Approved [5]
Spiramycin DM20R5F Bacterial infection 1A00-1C4Z Approved [6]
Thiamphenicol DMDRKH2 Bacterial infection 1A00-1C4Z Approved [7]
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⏷ Show the Full List of 7 Approved Drug(s)
3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cethromycin DMIGX84 Bacterial infection 1A00-1C4Z Phase 3 [8]
EDP-420 DM5WZ0O Bacterial infection 1A00-1C4Z Phase 2 [9]
Oxazolidinones DMBM47Z Gram-positive bacterial infection 1B74-1G40 Phase 2 [10]
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2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Micrococcin DMJ4D1P Discovery agent N.A. Investigative [6]
Thiostrepton DML7Y1R Discovery agent N.A. Investigative [6]
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References

1 Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23.
2 Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol. 2004 Dec;54(5):1287-94.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
4 Company report (JMI Laboratories)
5 Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
6 The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
7 The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-9-13.
8 How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
9 EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May; 51(5): 1666-1670.
10 Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.