Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLN1AP)

• DTT Name: Alpha-methylacyl-CoA racemase (AMACR)
• Synonyms: IBLi; 2-methylacyl-CoA racemase
• Gene Name: AMACR
• DTT Type: Literature-reported target; [1]
• BioChemical Class: CaiB/BaiF CoA-transferase family
• UniProt ID: AMACR_HUMAN
• TTD ID: T92768
• EC Number: EC 5.1.99.4
• Sequence:
  MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQP
  RGAAVLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLA
  GHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
  DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQF
  YELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTF
  EEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEHTEEILEEFGFS
  REEIYQLNSDKIIESNKVKASL
• Function: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
• KEGG Pathway:
  Primary bile acid biosynthesis (hsa00120)
  Metabolic pathways (hsa01100)
  Peroxisome (hsa04146)
• Reactome Pathway:
  Synthesis of bile acids and bile salts via 24-hydroxycholesterol (R-HSA-193775)
  Beta-oxidation of pristanoyl-CoA (R-HSA-389887)
  Peroxisomal protein import (R-HSA-9033241)
  Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (R-HSA-193368)
• BioCyc Pathway: MetaCyc:HS01416-MON

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Alpha-methylacyl-CoA racemase (AMACR) DME Info
• Gene Name: AMACR

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexibuprofen	DMFYBD0	Ankylosing spondylitis	FA92.0	Approved	[2]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]

References

• [1] [The value of alpha-methylacyl-CoA racemase expression in the progression of colonic carcinoma]. Rev Esp Patol. 2017 Jan - Mar;50(1):15-21.
• [2] Alpha-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. Prog Lipid Res. 2013 Apr;52(2):220-30.
• [3] Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology. 2009 Dec;17(6):275-342.