Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLP3GX)

DTT Name Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC)
Synonyms algC; PMM/PGM; PMM / PGM
Gene Name Pseudo algC
DTT Type
Literature-reported target
 [1]
BioChemical Class
Intramolecular transferases
UniProt ID
ALGC_PSEAE
TTD ID
T85801
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTAKAPTLPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEPCVAVGRDGRLS
GPELVKQLIQGLVDCGCQVSDVGMVPTPVLYYAANVLEGKSGVMLTGSHNPPDYNGFKIV
VAGETLANEQIQALRERIEKNDLASGVGSVEQVDILPRYFKQIRDDIAMAKPMKVVVDCG
NGVAGVIAPQLIEALGCSVIPLYCEVDGNFPNHHPDPGKPENLKDLIAKVKAENADLGLA
FDGDGDRVGVVTNTGTIIYPDRLLMLFAKDVVSRNPGADIIFDVKCTRRLIALISGYGGR
PVMWKTGHSLIKKKMKETGALLAGEMSGHVFFKERWFGFDDGIYSAARLLEILSQDQRDS
EHVFSAFPSDISTPEINITVTEDSKFAIIEALQRDAQWGEGNITTLDGVRVDYPKGWGLV
RASNTTPVLVLRFEADTEEELERIKTVFRNQLKAVDSSLPVPF
Function
Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity (PubMed:10481091). Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-108 to the substrate (generatinga bisphosphorylated substrate intermediate and a dephosphorylated enzyme), a 180 degree rotation of the intermediate (probably aided by movement of domain 4), and subsequent transfer of phosphate back to the enzyme (PubMed:11716469, PubMed:16880541, PubMed:16595672, PubMed:22242625).
BioCyc Pathway
MetaCyc:MON-19202

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
5 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alpha-D-Glucose-1-Phosphate DMU36HT Discovery agent N.A. Investigative [1]
Alpha-D-Glucose-6-Phosphate DMR0EVN Discovery agent N.A. Investigative [1]
Alpha-D-Mannose-6-Phosphate DM3NCM1 Discovery agent N.A. Investigative [1]
D-Mannose 1-Phosphate DM7O1IW Discovery agent N.A. Investigative [1]
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.